Centre for Health Equity Studies (CHESS), Stockholm University/Karolinska Institutet, , Stockholm, Sweden.
J Epidemiol Community Health. 2013 Nov 1;67(11):939-46. doi: 10.1136/jech-2012-202149. Epub 2013 May 31.
Childhood and adulthood socio-economic position (SEP) is associated with cardiovascular disease in later life, but associations with hypertensive disorders in pregnancy are not well established.
The aim of this study was to investigate the association of childhood and adulthood SEP with hypertensive disorders in pregnancy (chronic hypertension, gestational hypertension and pre-eclampsia/eclampsia).
Study participants were Swedish women (n=9507) from generation 3 of the Uppsala Birth Cohort Multigenerational Study (UBCoS Multigen) who delivered a live singleton offspring between 1982 and 2008. Social and health data were obtained from routine Swedish registers. Associations of own education (adulthood SEP), and parental education and social class (childhood SEP) with hypertensive disorders were studied using logistic regression with adjustments for age, calendar period, parity, smoking and body mass index.
Low own education was associated with chronic hypertension, but not with gestational hypertension or pre-eclampsia/eclampsia. Increased risk of chronic hypertension was seen in women whose mothers had medium education compared with women whose mothers had high education (OR 2.18, 95% CI 1.03 to 4.62). Women from a manual social class during childhood had twice the risk of chronic hypertension compared with those from non-manual backgrounds (OR 2.19, 95% CI 1.28 to 3.75). Childhood SEP was not associated with gestational hypertension or pre-eclampsia/eclampsia.
Childhood and adulthood SEP was associated with chronic hypertension in pregnancy. In contrast, no association with childhood or adulthood SEP was seen for gestational hypertension or pre-eclampsia/eclampsia.
儿童期和成年期的社会经济地位（SEP）与晚年的心血管疾病有关，但与妊娠高血压疾病的关联尚未得到充分证实。
本研究旨在探讨儿童期和成年期 SEP 与妊娠高血压疾病（慢性高血压、妊娠期高血压和子痫前期/子痫）的关系。
研究参与者为乌普萨拉出生队列多代研究（UBCoS Multigen）第三代的瑞典女性（n=9507），她们于 1982 年至 2008 年间分娩了单胎活产儿。社会和健康数据来自常规瑞典登记处。使用逻辑回归，调整年龄、日历期、产次、吸烟和体重指数，研究自身教育（成年 SEP）和父母教育及社会阶层（儿童期 SEP）与高血压疾病的关系。
低自身教育与慢性高血压有关，但与妊娠期高血压或子痫前期/子痫无关。与母亲受过高等教育的女性相比，母亲受过中等教育的女性发生慢性高血压的风险增加（OR 2.18，95%CI 1.03 至 4.62）。儿童期来自体力劳动社会阶层的女性发生慢性高血压的风险是来自非体力劳动背景的女性的两倍（OR 2.19，95%CI 1.28 至 3.75）。儿童期 SEP 与妊娠期高血压或子痫前期/子痫无关。
儿童期和成年期 SEP 与妊娠慢性高血压有关。相比之下，儿童期或成年期 SEP 与妊娠期高血压或子痫前期/子痫无关。
