术前 18F-FDG PET/CT 和高危型人乳头瘤病毒在口咽鳞状细胞癌患者中的应用。
Preoperative 18F-FDG PET/CT and high-risk HPV in patients with oropharyngeal squamous cell carcinoma.
机构信息
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
出版信息
Head Neck. 2014 Mar;36(3):323-7. doi: 10.1002/hed.23296. Epub 2013 Jun 1.
BACKGROUND
To evaluate the association of (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG PET/CT) and high-risk human papillomavirus (HPV) status and to establish the histologic correlates in oropharyngeal cancer (OPSCC).
METHOD
The medical records of 78 patients who underwent (18)F-FDG PET/CT for OPSCC before surgery were reviewed.
RESULTS
The positive rate of high-risk HPV in situ hybridization was 36% (28 of 78). The maximum standardized uptake values (SUVmax ) of negativity for the high-risk HPV subtypes (10.29 ± 4.30) and positivity (6.69 ± 4.17) were found to be significantly different (p = .001). The SUVmax cutoff value for differentiating negativity for the high-risk HPV subtypes from positivity was 7.10, with the sensitivity of 78% and the specificity of 68%. A median SUVmax (using 7.10 as a cutoff) (p = .041) and high-risk HPV status (p = .040) were found to be associated with 5-year disease-specific survival (DSS).
CONCLUSIONS
Median (18)F-FDG PET/CT SUVmax cutoff values 7.10 or greater are associated with a high-risk HPV negativity in OPSCC patients.
背景
评估（18）F-氟脱氧葡萄糖正电子发射断层扫描（（18）F-FDG PET/CT）与高危型人乳头瘤病毒（HPV）状态的相关性，并建立口咽癌（OPSCC）的组织学相关性。
方法
回顾了 78 例接受 OPSCC 手术前（18）F-FDG PET/CT 的患者的病历。
结果
高危型 HPV 原位杂交的阳性率为 36%（28/78）。高危 HPV 亚型阴性的最大标准化摄取值（SUVmax）（10.29±4.30）和阳性（6.69±4.17）的 SUVmax 值差异有统计学意义（p=0.001）。区分高危 HPV 亚型阴性和阳性的 SUVmax 截断值为 7.10，敏感性为 78%，特异性为 68%。SUVmax 中位数（使用 7.10 作为截断值）（p=0.041）和高危 HPV 状态（p=0.040）与 5 年疾病特异性生存（DSS）相关。
结论
（18）F-FDG PET/CT SUVmax 中位数截断值≥7.10 与 OPSCC 患者高危 HPV 阴性相关。
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