Ishola Ismail O, Awodele Olufunsho, Oreagba Ibrahim A, Murtala Abdulahi A, Chijioke Micah C
J Basic Clin Physiol Pharmacol. 2013;24(4):277-86. doi: 10.1515/jbcpp-2013-0005.
Strophanthus hispidus DC (Apocynaceae) is a medicinal plant widely used in traditional African medicine in the treatment of rheumatic afflictions, ulcer, conjunctivitis, leprosy and skin diseases. This study sought to investigate the antinociceptive, anti-inflammatory and antiulcer properties of the ethanol root extract of S. hispidus.
Antinociceptive activity was evaluated using acetic acid-induced writhing and formalin tests in mice. The carrageenan- and egg albumin-induced rat paw edema tests were used to investigate the anti-inflammatory actions, whereas the antiulcer activity was investigated using ethanol-, HCl- and pyloric ligation-induced gastric ulcer models in rats.
S. hispidus [100-800 mg/kg orally (po)] produced significant (p<0.05) inhibition of writhing reflex with peak effect of 74.13% inhibition observed at 800 mg/kg. Similarly, S. hispidus significantly (p<0.05) attenuated formalin-induced early and late phase of nociception with peak effect of 61.84% and 89.43%, respectively, at 200 mg/kg. S. hispidus (25-800 mg/kg po) caused significant (p<0.05) inhibition of edema development in the carrageenan and egg albumin models with peak effect (93.40% and 90.10% inhibition of edema formation) observed at 50 mg/kg. With respect to antiulcer activity, S. hispidus (100-800 mg/kg) showed potent antiulcer activity with respective peak effects of 96% (ethanol-induced), 99% (HCl-induced) and 70.60% inhibition of ulcer.
The findings in this study suggest that the ethanol root extract of S. hispidus possesses antinociceptive, anti-inflammatory and antiulcerogenic activities. This justifies the use of the extract in folklore medicine for the treatment of ulcer and inflammatory disorders.
糙毛毒毛旋花（夹竹桃科）是一种药用植物，在非洲传统医学中广泛用于治疗风湿疾病、溃疡、结膜炎、麻风病和皮肤病。本研究旨在探究糙毛毒毛旋花乙醇根提取物的抗伤害感受、抗炎和抗溃疡特性。
采用乙酸诱导的扭体试验和福尔马林试验评估小鼠的抗伤害感受活性。角叉菜胶和蛋清诱导的大鼠足趾肿胀试验用于研究抗炎作用，而抗溃疡活性则通过乙醇、盐酸和幽门结扎诱导的大鼠胃溃疡模型进行研究。
糙毛毒毛旋花[口服（po）100 - 800 mg/kg]对扭体反射产生显著（p<0.05）抑制，在800 mg/kg时观察到的最大抑制率为74.13%。同样，糙毛毒毛旋花在200 mg/kg时分别对福尔马林诱导的伤害感受早期和晚期产生显著（p<0.05）减轻，最大抑制率分别为61.84%和89.43%。糙毛毒毛旋花（口服25 - 800 mg/kg）对角叉菜胶和蛋清模型中的水肿形成产生显著（p<0.05）抑制，在50 mg/kg时观察到最大抑制效果（水肿形成抑制率分别为93.40%和90.10%）。关于抗溃疡活性，糙毛毒毛旋花（100 - 800 mg/kg）表现出强效抗溃疡活性，对乙醇诱导、盐酸诱导和幽门结扎诱导的溃疡的最大抑制率分别为96%、99%和70.60%。
本研究结果表明糙毛毒毛旋花乙醇根提取物具有抗伤害感受、抗炎和抗溃疡活性。这证明了该提取物在民间医学中用于治疗溃疡和炎症性疾病的合理性。
