Roldão Erika de Freitas, Witaicenis Aline, Seito Leonardo Noboru, Hiruma-Lima Clélia Akiko, Di Stasi Luiz Claudio
Laboratory of Phytomedicines, Department of Pharmacology, Instituto de Biociências, São Paulo State University (UNESP), Botucatu, 18618-000, São Paulo, Brazil.
J Ethnopharmacol. 2008 Sep 2;119(1):94-8. doi: 10.1016/j.jep.2008.06.001. Epub 2008 Jun 6.
Cordia verbenacea is a medicinal plant popularly used in Brazil as anti-inflammatory, antiulcer and anti-rheumatic agent without detailed pharmacological and toxicological studies.
The study was aimed to investigate the effects of Cordia verbenacea in antiulcer, analgesic and antioxidant assays, as well as to evaluate its toxic effects and phytochemical profile.
Antiulcer activity of plant extract was evaluated using ethanol/HCl, ethanol and piroxican-induced gastric lesions methods. The pH, volume and total acid of gastric juice were determined by pylorus-ligated assay. Analgesic activity was evaluated by writhing, tail-flick and hot-plate tests. Antioxidant activity was determined by in vitro lipoperoxidation assay. Acute toxicity and number of deaths were evaluated by Hippocratic screening.
The ethanol leaf extract shows a potent antiulcer activity in the ethanol/HCl and absolute ethanol-induced gastric lesions. The IC(50) value of plant extract on the lipid peroxidation was 76.11mug/ml. Preliminary phytochemical tests were positive for flavonoids, steroids, saponins, fixed acids, alkaloids and phenols. In the analgesic models the extract did not present any activity.
Cordial verbenaceae showed a potent antiulcer activity at the dose of 125mg/kg and this effect may be associated with an improvement in stomach antioxidant mechanisms.
马鞭草科破布木是一种药用植物，在巴西广泛用于抗炎、抗溃疡和抗风湿，但缺乏详细的药理和毒理学研究。
本研究旨在探讨马鞭草科破布木在抗溃疡、镇痛和抗氧化试验中的作用，并评估其毒性作用和植物化学特征。
采用乙醇/盐酸、乙醇和吡罗昔康诱导的胃损伤方法评估植物提取物的抗溃疡活性。通过幽门结扎试验测定胃液的pH值、体积和总酸量。通过扭体、甩尾和热板试验评估镇痛活性。通过体外脂质过氧化试验测定抗氧化活性。通过希波克拉底筛选法评估急性毒性和死亡数量。
乙醇叶提取物在乙醇/盐酸和无水乙醇诱导的胃损伤中显示出强大的抗溃疡活性。植物提取物对脂质过氧化的IC(50)值为76.11μg/ml。初步植物化学试验表明，提取物中含有黄酮类、甾体类、皂苷类、固定酸类、生物碱类和酚类。在镇痛模型中，提取物未表现出任何活性。
马鞭草科破布木在125mg/kg剂量下显示出强大的抗溃疡活性，这种作用可能与胃抗氧化机制的改善有关。
