Clinical Research Department, Centre for Plant Medicine Research, Mampong-Akuapem, Ghana.
Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Biomed Res Int. 2021 May 5;2021:5574041. doi: 10.1155/2021/5574041. eCollection 2021.
The growth or multiplication of harmful microorganisms in addition to harmful human activities has led to many disorders in humans. Consequently, there is a search for medications to treat these disorders. Interestingly, medicines of plant origin are known to be among the most attractive sources of new drugs and have shown promising results in the treatment of various diseases including peptic ulcers. This review, therefore, is aimed at obtaining knowledge on some Ghanaian ethnomedicinal plants used to treat peptic ulcers, their folkloric uses, their phytochemicals, and their antiulcer and related pharmacological activities as well as finding areas for prospective studies.
Published peer-reviewed articles on ethnomedicinal plants used for the management of peptic ulcers in Ghana from 1967 to 2020 were sourced and used for the study.
In this review, 13 plants were identified which belong to 10 different families including Sapindaceae, Apocynaceae, and Bignoniaceae. The parts most often used for most preparations were the leaves (53%), followed by stem bark and roots (both having the same percentage of use of 17.6%), the whole plant (5.9%), and the rhizomes (5.9%). was the only plant that had undergone some patient studies in addition to animal studies. A discussion of various antiulcer activity studies using ulcer models carried out on selected medicinal plants used for the management of peptic ulcer disease in addition to brief information on their folkloric uses and their phytochemical and other pharmacological properties is presented. These medicinal plants may be used in developing herbal products for the management of peptic ulcer disease.
有害微生物的生长和繁殖以及有害人类活动导致了许多人类疾病。因此，人们一直在寻找治疗这些疾病的药物。有趣的是，植物来源的药物被认为是最有吸引力的新药来源之一，并且在治疗各种疾病方面显示出了有希望的结果，包括消化性溃疡。因此，本综述旨在获取一些用于治疗消化性溃疡的加纳传统药用植物的知识，包括它们的民间用途、植物化学物质、抗溃疡和相关的药理学活性，并寻找有前景的研究领域。
从 1967 年到 2020 年，我们搜索并使用了发表的关于加纳用于治疗消化性溃疡的传统药用植物的同行评审文章。
在本综述中，确定了 13 种植物，它们属于 10 个不同的科，包括无患子科、夹竹桃科和紫葳科。最常用于大多数制剂的部分是叶子（53%），其次是茎皮和根（使用百分比相同，均为 17.6%）、整株植物（5.9%）和根茎（5.9%）。是唯一一种除了动物研究外，还进行了一些患者研究的植物。本文还讨论了使用选定的药用植物进行的各种抗溃疡活性研究，这些药用植物用于治疗消化性溃疡疾病，此外还简要介绍了它们的民间用途、植物化学和其他药理学特性。这些药用植物可用于开发用于治疗消化性溃疡疾病的草药产品。
