Nwosu Benjamin Udoka, Snook Rachel I, Maranda Louise
J Pediatr Endocrinol Metab. 2013;26(9-10):819-24. doi: 10.1515/jpem-2012-0312.
The pathogenesis of short stature in celiac disease (CD) is unknown. Obese children are generally taller than their non-obese peers; however, the role of adiposity on stature in CD is unclear. Our aim was to determine the association between adiposity and stature in CD.
We compared the anthropometric characteristics of prepubertal children of ages 3-12 years, with biopsy-proven CD (n=40) and who were not on gluten-free diet, to same aged, prepubertal non-CD children (n=50). Body mass index (BMI) was calculated using the formula weight/height². Sex-adjusted midparental target height (MPTH) standard deviation score (SDS) was calculated using National Children Health Statistics data for 18-year-old adults. Data were expressed as mean ± standard deviation.
CD subjects had significantly lower BMI SDS than controls (0.61 ± 1.22 vs. 1.28 ± 1.60, p=0.027) but were not significantly shorter than the controls (-0.05 ± 1.21 vs. 0.21 ± 1.71, p=0.41). When the patients were subdivided into the normal-weight and overweight/obese groups, the normal-weight CD patients were of similar height as the normal-weight controls (p=0.76) but were significantly shorter than both the overweight/obese controls (p<0.001) and overweight/obese CD children (p<0.001). Interestingly, the overweight/obese CD children were significantly taller than the normal-weight controls (p=0.003). The MPTH SDS did not differ between the groups.
Overweight/obese prepubertal children with CD were taller than both their normal-weight CD peers and the normal-weight controls, but were of similar height as the overweight/obese control subjects.
乳糜泻（CD）导致身材矮小的发病机制尚不清楚。肥胖儿童通常比非肥胖同龄人更高；然而，肥胖对CD患者身高的影响尚不清楚。我们的目的是确定CD患者中肥胖与身高之间的关联。
我们将3至12岁经活检证实为CD且未采用无麸质饮食的青春期前儿童（n = 40）的人体测量特征与同年龄的青春期前非CD儿童（n = 50）进行比较。体重指数（BMI）采用体重/身高²公式计算。使用18岁成年人的国家儿童健康统计数据计算性别调整后的父母平均身高（MPTH）标准差评分（SDS）。数据以平均值±标准差表示。
CD患者的BMI SDS显著低于对照组（0.61±1.22 vs. 1.28±1.60，p = 0.027），但身高并不显著低于对照组（-0.05±1.21 vs. 0.21±1.71，p = 0.41）。当将患者分为正常体重组和超重/肥胖组时，正常体重的CD患者身高与正常体重对照组相似（p = 0.76），但显著低于超重/肥胖对照组（p < 0.001）和超重/肥胖的CD儿童（p < 0.001）。有趣的是，超重/肥胖的CD儿童显著高于正常体重对照组（p = 0.003）。两组之间的MPTH SDS没有差异。
超重/肥胖的青春期前CD儿童比正常体重的CD同龄人及正常体重对照组更高，但与超重/肥胖的对照受试者身高相似。
