乳糖不耐受：在青春期前儿童中，没有证据表明存在身材矮小或维生素 D 缺乏的情况。
Lactose intolerance: lack of evidence for short stature or vitamin D deficiency in prepubertal children.
机构信息
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
出版信息
PLoS One. 2013 Oct 25;8(10):e78653. doi: 10.1371/journal.pone.0078653. eCollection 2013.
BACKGROUND
The health consequences of lactose intolerance (LI) are unclear.
AIMS
To investigate the effects of LI on stature and vitamin D status.
HYPOTHESES
LI subjects will have similar heights and vitamin D status as controls.
SUBJECTS AND METHODS
Prepubertal children of ages 3-12 years with LI (n=38, age 8.61 ± 3.08y, male/female 19/19) were compared to healthy, age- and gender-matched controls (n=49, age 7.95±2.64, male/female 28/21).
INCLUSION CRITERIA
prepubertal status (boys: testicular volume <3cc; girls: Tanner 1 breasts), diagnosis of LI by hydrogen breath test, and no history of calcium or vitamin D supplementation. Vitamin D deficiency was defined as 25-hydroxyvitamin D [25(OH)D] <50 nmol/L. Gender-adjusted midparental target height (MPTH) z-score was calculated using NCHS data for 18 year-old adults. Data were expressed as mean ± SD.
RESULTS
There was no significant difference in 25(OH)D between the LI and non-LI subjects (60.1±21.1, vs. 65.4 ± 26.1 nmol/L, p = 0.29). Upon stratification into normal weight (BMI <85(th) percentile) vs. overweight/obese (BMI ≥85(th) percentile), the normal weight controls had significantly higher 25(OH)D level than both the normal weight LI children (78.3 ± 32.6 vs. 62.9 ± 23.2, p = 0.025), and the overweight/obese LI children (78.3±32.6 vs. 55.3±16.5, p = 0.004). Secondly, there was no overall difference in height z-score between the LI children and controls. The normal weight LI patients had similar height as normal controls (-0.46 ± 0.89 vs. -0.71 ± 1.67, p = 0.53), while the overweight/obese LI group was taller than the normal weight controls (0.36 ± 1.41 vs. -0.71 ± 1.67, p = 0.049), and of similar height as the overweight/obese controls (0.36 ± 1.41 vs. 0.87 ± 1.45, p = 0.28). MPTH z-score was similar between the groups.
CONCLUSION
Short stature and vitamin D deficiency are not features of LI in prepubertal children.
背景
乳糖不耐受（LI）的健康后果尚不清楚。
目的
研究 LI 对身高和维生素 D 状况的影响。
假设
LI 受试者的身高和维生素 D 状况与对照组相似。
受试者和方法
将年龄在 3-12 岁的乳糖不耐受（LI）的青春期前儿童（n=38，年龄 8.61 ± 3.08y，男/女 19/19）与健康、年龄和性别匹配的对照组（n=49，年龄 7.95±2.64，男/女 28/21）进行比较。
纳入标准
青春期前状态（男孩：睾丸体积<3cc；女孩：Tanner 1 乳房），通过氢呼气试验诊断为 LI，且无钙或维生素 D 补充史。维生素 D 缺乏症定义为 25-羟维生素 D [25（OH）D] <50 nmol/L。使用 NCHS 数据计算性别调整后的中亲身高目标值（MPTH）z 分数，适用于 18 岁成年人。数据表示为平均值 ± SD。
结果
LI 和非 LI 受试者的 25（OH）D 无显著差异（60.1±21.1，vs. 65.4 ± 26.1 nmol/L，p = 0.29）。在分层为正常体重（BMI <85 百分位）与超重/肥胖（BMI ≥85 百分位）时，正常体重对照组的 25（OH）D 水平明显高于正常体重 LI 儿童（78.3 ± 32.6 vs. 62.9 ± 23.2，p = 0.025），也高于超重/肥胖 LI 儿童（78.3±32.6 vs. 55.3±16.5，p = 0.004）。其次，LI 儿童与对照组之间的身高 z 评分无总体差异。正常体重 LI 患者的身高与正常对照组相似（-0.46 ± 0.89 vs. -0.71 ± 1.67，p = 0.53），而超重/肥胖 LI 组的身高高于正常体重对照组（0.36 ± 1.41 vs. -0.71 ± 1.67，p = 0.049），与超重/肥胖对照组的身高相似（0.36 ± 1.41 vs. 0.87 ± 1.45，p = 0.28）。两组的 MPTH z 评分相似。
结论
在青春期前儿童中，身材矮小和维生素 D 缺乏不是乳糖不耐受的特征。
Zotero 插件