Wyse R K, Mars M, al-Mahdawi S, Russell-Eggitt I M, Blake K D
Department of Paediatric Cardiology, Institute of Child Health, London, United Kingdom.
Cleft Palate J. 1990 Jul;27(3):258-64; discussion 264-5. doi: 10.1597/1545-1569(1990)027<0258:chaipw>2.3.co;2.
The nature and severity of congenital heart disease in 78 patients who presented with clefts of the lip and/or palate is reported. The prevalence of bilateral cleft lip and palate in patients with heart lesions was much higher than in cleft patients with normal hearts. Cardiac defects were predominantly conotruncal. Tetralogy of Fallot was present in 24 percent of patients; the prevalence of transposition, atrioventricular septal defect, and truncus arteriosus was also disproportionately high. Patients with conotruncal defects had a greater prevalence of either unilateral or bilateral cleft lip and palate. Most patients with congenital heart disease and clefting had additional abnormalities. Anomalies of other systems were found to be present in 87 percent of patients.
报告了78例唇裂和/或腭裂患者先天性心脏病的性质和严重程度。有心脏病变的双侧唇腭裂患者的患病率远高于心脏正常的腭裂患者。心脏缺陷主要是圆锥动脉干型。24%的患者存在法洛四联症；大动脉转位、房室间隔缺损和动脉干异常的患病率也不成比例地高。圆锥动脉干缺损患者单侧或双侧唇腭裂的患病率更高。大多数先天性心脏病和腭裂患者还有其他异常。87%的患者发现有其他系统异常。
