Rouger P, Gugenheim J, Gane P, Capron-Landereau M, Michel F, Reynes M, Bismuth J
Institut National de Transfusion Sanguine, Université Pierre et Marie Curie, Paris, France.
Clin Exp Immunol. 1990 Jun;80(3):404-8. doi: 10.1111/j.1365-2249.1990.tb03301.x.
The aim of this study was to analyse the change in tissue distribution of HLA class I and class II molecules in patients during the course of liver transplantation. Sixty-one liver biopsies were analysed in 24 patients with or without rejection (acute or chronic) episode. In 93% of cases with chronic rejection and in 48% of cases with acute rejection episodes, HLA class I antigens are expressed in the membrane and/or the cytoplasm of hepatocytes. The expression of these molecules was significantly correlated with the ASP (aspartate amino transferase), AP (alkaline phosphatase), the bile duct damage and the centrolobular lesions. In contrast, the expression of HLA class II molecules is not correlated with either the type of rejection, the biological or histological findings. A strong expression of HLA class I antigen on hepatocytes after day 60 may be one of the best signs of chronic rejection.
本研究的目的是分析肝移植患者在病程中HLA I类和II类分子的组织分布变化。对24例有或无排斥反应（急性或慢性）发作的患者的61份肝活检组织进行了分析。在93%的慢性排斥反应病例和48%的急性排斥反应发作病例中，HLA I类抗原在肝细胞的细胞膜和/或细胞质中表达。这些分子的表达与天冬氨酸转氨酶（ASP）、碱性磷酸酶（AP）、胆管损伤和小叶中心病变显著相关。相比之下，HLA II类分子的表达与排斥反应类型、生物学或组织学结果均无相关性。术后60天以后肝细胞上HLA I类抗原的强表达可能是慢性排斥反应的最佳征象之一。
