Prasanna J S
Department of Periodontics, Panineeya Mahavidyalaya Institute of Dental Sciences and Research Centre, Kamala Nagar, Road No-5, Dilsukh Nagar, Hyderabad, 500 060 India.
J Maxillofac Oral Surg. 2012 Jun;11(2):212-9. doi: 10.1007/s12663-011-0318-6. Epub 2012 Feb 5.
The lingering numbness that can last anywhere from 3 to 5 h after a routine dental procedure is often an unnecessary, inconvenient hassle. Patients may find that their ability to speak, smile, eat and drink is impaired, and may even have uncontrollable drooling. The effects of local dental anesthetics can now be reversed. That's because OraVerse, an anesthetic reversal agent, can return the patient to normal sensation and function in about half the time. OraVerse which is U.S. Food and Drug Administration approved is a safe and effective form of phentolamine mesylate, a vasodilator that has been used in several other medical applications since 1952. OraVerse injection - the first and only proven safe and effective product of its kind can quickly reverse the effects of local dental anesthetics, so patient can carry on without impairment of talk, smile and drink after dental procedures. Studies also have shown that there are no known drug interactions and no evident toxicity or contraindications for using OraVerse.
常规牙科手术后持续3至5小时的麻木感往往是不必要且带来不便的麻烦。患者可能会发现自己说话、微笑、进食和饮水的能力受到损害,甚至可能出现无法控制的流口水现象。现在,局部牙科麻醉剂的效果可以被逆转。这是因为一种名为奥芮沃斯(OraVerse)的麻醉逆转剂能够让患者在大约一半的时间内恢复正常感觉和功能。奥芮沃斯已获得美国食品药品监督管理局的批准,是甲磺酸酚妥拉明的一种安全有效的形式,自1952年以来,甲磺酸酚妥拉明已被用于其他多种医疗应用。奥芮沃斯注射剂——同类产品中首个也是唯一经证实安全有效的产品——能够迅速逆转局部牙科麻醉剂的效果,这样患者在牙科手术后就能够正常说话、微笑和饮水而不受影响。研究还表明,使用奥芮沃斯不存在已知的药物相互作用,也没有明显的毒性或禁忌。