Reynolds Luke F, Mailman Timothy L, McMillan Douglas D
Faculty of Medicine;
Paediatr Child Health. 2012 Jun;17(6):310-2.
Serum gentamicin concentrations (GSCs) are frequently obtained before and after gentamicin administration to newborns with, or at high risk for, sepsis.
To determine whether performing a peak GSC assay when the trough GSC is within the guidelines for care would add clinically relevant information for health care workers.
A retrospective review of the IWK Health Centre (Halifax, Nova Scotia) laboratory database for peak and trough GSC for infants <28 days after birth was performed.
Of 5253 paired samples of trough and peak GSCs, 3001 (57%) had trough GSCs ≤2 μg/mL. Of these, only nine (0.3%) had a peak GSC >10 μg/mL.
Performing a peak GSC measurement does not provide further clinically important data and increases patient morbidity and hospital costs.
对于患有败血症或有败血症高风险的新生儿，经常在给予庆大霉素之前和之后检测血清庆大霉素浓度（GSCs）。
确定当谷浓度GSC在护理指南范围内时进行峰浓度GSC检测是否会为医护人员增加临床相关信息。
对IWK健康中心（新斯科舍省哈利法克斯）实验室数据库中出生后<28天婴儿的谷浓度和峰浓度GSC进行回顾性分析。
在5253对谷浓度和峰浓度GSC样本中，3001例（57%）谷浓度GSC≤2μg/mL。其中，只有9例（0.3%）峰浓度GSC>10μg/mL。
进行峰浓度GSC测量并不能提供更多具有临床重要性的数据，反而会增加患者发病率和医院成本。
