[用人血浆纤连蛋白滴眼液治疗持续性角膜上皮病变]

[Treatment of persistent corneal epithelial disorders with human plasma fibronectin eyedrops].

作者信息

Qu X A

机构信息

Beijing Institute of Ophthalmology.

出版信息

Zhonghua Yan Ke Za Zhi. 1990 Jan;26(1):21-3.

PMID:2373030

Abstract

Fibronectin (FN), a glycoprotein present in plasma and the extracellular matrix, is responsible for cellular adhesion. 14 eyes with persistent corneal epithelial defects of various etiology were treated with FN to evaluate its effect on corneal epithelial wound healing. Human plasma fibronectin eyedrops (200 micrograms/ml) were instilled 5 times in addition to gentamycin eyedrops 2 times a day. The eyes healed completely in an average 20.4 days, with no recurrence in follow-ups of 1 to 3 months.

摘要

纤连蛋白（FN）是一种存在于血浆和细胞外基质中的糖蛋白，负责细胞黏附。对14只因各种病因导致持续性角膜上皮缺损的眼睛使用纤连蛋白进行治疗，以评估其对角膜上皮伤口愈合的影响。除每天滴注2次庆大霉素眼药水外，还滴注5次人血浆纤连蛋白眼药水（200微克/毫升）。这些眼睛平均在20.4天内完全愈合，在1至3个月的随访中无复发。