[Treatment of experimental HSV keratitis with recombinant human interferon (rHuIFN): a clinical and scanning electron microscopic study].

Treatment of experimental HSV keratitis in rabbits with rHuIFN alpha-1 instillations was studied Clinical and scanning electron microscopic observations revealed that local application of rHuIFN alpha-1 protected the target cells against virus invasion and restrained development of HSV keratitis. The initial punctate lesions did not expand uniformly but linearly to form dendritic patterns due to varying sensitivity of cells to virus.