Division of Surgical Oncology and Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
J Gastrointest Oncol. 2013 Jun;4(2):164-72. doi: 10.3978/j.issn.2078-6891.2013.005.
In era of systemic chemotherapy for colorectal liver metastasis (CLM), role of hepatic intraarterial infusion chemotherapy (HAIC) remains important. We examined treatment effects of HAIC in 36 patients with non-resectable CLM using 5-FU or CPT-11. Tumor response was complete response (CR) in 4, partial response (PR) in 19, stable disease (SD) in 6, and progressive disease (PD) in 7. Tumor control rate was 81% and response rate was 64%. Six patients showed catheter-related complications. Median survival period was 62 months in CR, and 25 with PR. HAIC has a major impact in high chemotherapy response and prolonging survival.
在结直肠癌肝转移（CLM）的系统化疗时代，肝动脉内灌注化疗（HAIC）的作用仍然很重要。我们用 5-FU 或 CPT-11 检查了 36 例不可切除的 CLM 患者的 HAIC 治疗效果。肿瘤反应完全缓解（CR）4 例，部分缓解（PR）19 例，疾病稳定（SD）6 例，疾病进展（PD）7 例。肿瘤控制率为 81%，反应率为 64%。6 例患者出现导管相关并发症。CR 中位生存期为 62 个月，PR 为 25 个月。HAIC 对高化疗反应和延长生存期有重大影响。
