Kumar Arun, Sathian Brijesh
Associate Professor, Department of Biochemistry, International Medical School, Management and Science University, Shah Alam Campus, Selangor, Malaysia.
Asian Pac J Trop Biomed. 2013 Jun;3(6):487-91. doi: 10.1016/S2221-1691(13)60101-X.
To study the usefulness of traditional lipid profile levels in screening subjects who had developed chest pain due to cardiac event as indicated by a positive troponin I test.
In this retrospective study data of the 430 patients presented to the emergency department with symptoms of cardiac ischemia who underwent both troponin and lipid profiles tests were compared with the lipid profiles of 165 normal healthy subjects (controls). The troponin was detected qualitatively when a specimen contains troponin I (cTnI) above the 99th percentile (TnI>0.5 ng/mL). The total cholesterol, high density lipoproteins cholesterol, very low density lipoproteins and triacyl glycerol levels were also analyzed and low density lipoprotein level was calculated using Friedewald's formula.
Patients with chest pain and positive troponin test (with confirmed cardiac event) were found to have significantly elevated levels of total cholesterol, triacyl glycerol levels, low density lipoprotein level and significantly reduced high density lipoproteins cholesterol levels when compared to the patients who experienced only chest pain (negative troponin) and healthy controls.
Traditional lipid profile levels is still can be used in screening populations to identify the subjects with high risk of developing cardiac event in case if the laboratory set up has not troponin test facilities.
研究传统血脂水平在筛查因肌钙蛋白I检测呈阳性而提示发生心脏事件导致胸痛的患者中的作用。
在这项回顾性研究中，将430例因心脏缺血症状就诊于急诊科并接受肌钙蛋白和血脂检测的患者的数据与165例正常健康受试者（对照组）的血脂数据进行比较。当标本中肌钙蛋白I（cTnI）高于第99百分位数（TnI>0.5 ng/mL）时，对肌钙蛋白进行定性检测。还分析了总胆固醇、高密度脂蛋白胆固醇、极低密度脂蛋白和三酰甘油水平，并使用Friedewald公式计算低密度脂蛋白水平。
与仅出现胸痛（肌钙蛋白阴性）的患者和健康对照组相比，胸痛且肌钙蛋白检测呈阳性（确诊心脏事件）的患者的总胆固醇、三酰甘油水平、低密度脂蛋白水平显著升高，高密度脂蛋白胆固醇水平显著降低。
如果实验室没有肌钙蛋白检测设备，传统血脂水平仍可用于筛查人群，以识别发生心脏事件高风险的患者。
