Gupta Bharat Kumar, Solanki Ranjan, Punia Himanshu, Agarwal Vibhuti, Kaur Jaskiran, Shukla Ashish
Post Graduate Student, Department of Biochemistry, Subharti Medical College, Swami Vivakan and Subharti University , Meerut, India .
Professor, Department of Biochemistry, Subharti Medical College, Swami Vivakan and Subharti University , Meerut, India .
J Clin Diagn Res. 2014 Aug;8(8):CC10-3. doi: 10.7860/JCDR/2014/8018.4694. Epub 2014 Aug 20.
National Health and Nutrition Examination Survey (NHANES III), 1988-1994, first time reported a significant, positive association in iron storage and heart disease risk. Thereafter several researchers have found an association between iron overload, serum ferritin (SF) and MI. No such Indian study was available in the literature and so we decided to find out the relation of lipid profile and Serum Ferritin with myocardial infarction (MI).
Fifty indian patients of AMI (study group) and fifty indian healthy volunteers (control group) were included for the present study. Lipid profile including TC, HDL-c, LDL-c, VLDL-c & TG and SF levels were estimated in all subjects.
Mean ± SD of TC level was 250.64 ± 25.61, of HDL-c was 36.52 ± 2.86, of LDL-c was 165.69 ± 26.80, of VLDL-c was 42.35 ± 8.53 and of TG was 211.83 ± 42.65 in study group while these values were 174.46±47.68, 43.2±12.52, 98.37±41.13, 32.88±21.45 and 164.42±107.29 respectively in control group. All the parameters were found not only raised in patients of acute myocardial infarction (AMI) but were also statistically significant when compared with control group (p=<0.01). Mean ± SD of SF levels was 268.43±30.17 ng/ml in study group and 110.96±56.5 ng/ml in control group; this level was found not only raised in patients of AMI but were also statistically significant when compared with control group (p=<0.01).
TC, LDL-c, VLDL-c, TG and SF levels were raised in patients of AMI and found to be statistically significant; while HDL-c levels were reduced in such patients and is also statistically significant. It can be concluded that there exists an association in lipid profile and SF with AMI therefore dyslipidemia and raised SF levels are the features of AMI.
1988 - 1994年的美国国家健康与营养检查调查（NHANES III）首次报告了铁储存与心脏病风险之间存在显著的正相关。此后，几位研究人员发现铁过载、血清铁蛋白（SF）与心肌梗死（MI）之间存在关联。文献中尚无此类印度的研究，因此我们决定探究血脂谱和血清铁蛋白与心肌梗死（MI）的关系。
本研究纳入了50名印度急性心肌梗死患者（研究组）和50名印度健康志愿者（对照组）。对所有受试者评估了包括总胆固醇（TC）、高密度脂蛋白胆固醇（HDL - c）、低密度脂蛋白胆固醇（LDL - c）、极低密度脂蛋白胆固醇（VLDL - c）和甘油三酯（TG）在内的血脂谱以及血清铁蛋白水平。
研究组中TC水平的均值±标准差为250.64±25.61，HDL - c为36.52±2.86，LDL - c为165.69±26.80，VLDL - c为42.35±8.53，TG为211.83±42.65；而对照组中这些值分别为174.46±47.68、43.2±12.52、98.37±41.13、32.88±21.45和164.42±10
