Ketavarapu Sameera, Ramani G Uma, Modi Prabhavathi
Assistant Professor, Department of Biochemistry, Katuri Medical College & Hospital Katuri Nagar, Chinakondrupadu, Guntur - 522 019, Andhra Pradesh, India .
J Clin Diagn Res. 2013 Apr;7(4):613-7. doi: 10.7860/JCDR/2013/4761.2865. Epub 2013 Apr 1.
Adenosine Deaminase (ADA) has been suggested to be an important enzyme which is associated with the cell mediated immunity, but its clinical significance in typhoid fever has not yet been characterized. The present study was taken up to evaluate the serum ADA activity in patients of typhoid fever. The levels of ADA were also measured in the patients who were suffering from other febrile illnesses.
This was a case control study. The subjects who were included in this study were divided into 3 groups. Group A consisted of 50 normal healthy individuals who served as the controls. Group B consisted of 50 patients, both males and females of all age groups, who were suffering from culture positive typhoid fever. Group C consisted of 50 patients who were suffering from febrile illnesses other than typhoid fever like viral fever, gastro enteritis, malaria, tonsillitis, upper respiratory tract infections, etc. The serum levels of ADA were estimated in all the subjects who were under study.
The serum ADA level was found to be increased in the patients of typhoid fever as compared to that in those with other febrile illnesses and in the controls.
From the present study, it can be concluded that there was a statistically significant increase in the serum ADA levels in the patients with typhoid.
腺苷脱氨酶（ADA）被认为是一种与细胞介导免疫相关的重要酶，但它在伤寒热中的临床意义尚未明确。本研究旨在评估伤寒热患者的血清ADA活性。还对患有其他发热性疾病的患者的ADA水平进行了测量。
这是一项病例对照研究。本研究纳入的受试者分为3组。A组由50名正常健康个体组成，作为对照组。B组由50名年龄各异的男性和女性患者组成，他们患有培养阳性的伤寒热。C组由50名患有除伤寒热以外的发热性疾病的患者组成，如病毒热、肠胃炎、疟疾、扁桃体炎、上呼吸道感染等。对所有研究对象的血清ADA水平进行了评估。
发现伤寒热患者的血清ADA水平高于其他发热性疾病患者和对照组。
从本研究可以得出结论，伤寒患者的血清ADA水平有统计学意义的升高。
