Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA.
J Viral Hepat. 2013 Jul;20(7):510-3. doi: 10.1111/jvh.12071. Epub 2013 Mar 25.
To investigate the effect of hepatitis B virus (HBV) infection on the development of diabetes mellitus (DM), we compared DM incidence and characteristics of Alaska Native persons with and without HBV infection. From 1990 to 2010, there were 52 incident DM cases among 1309 persons with infection vs 4557 DM cases among 85 698 persons without infection (log-rank test, P = 0.20). Compared to infected persons without DM, those with DM were significantly older (57.0 vs 47.4 years, P < 0.001) and had higher body mass index (34.5 vs 28.4 kg/m(2) , P < 0.001). Genotype, immune active disease and the presence of cirrhosis were not associated with DM. In this population-based cohort with over 20 years of follow-up, there was no effect of HBV infection on DM development.
为了探究乙型肝炎病毒(HBV)感染对糖尿病(DM)发展的影响,我们比较了感染 HBV 与未感染 HBV 的阿拉斯加原住民的 DM 发病率和特征。1990 年至 2010 年,在 1309 名感染者中,有 52 例新诊断的 DM,而在 85698 名未感染者中,有 4557 例 DM(对数秩检验,P=0.20)。与未感染 DM 的感染者相比,患有 DM 的感染者年龄明显更大(57.0 岁比 47.4 岁,P<0.001),且体重指数更高(34.5 千克/平方米比 28.4 千克/平方米,P<0.001)。基因型、免疫激活疾病和肝硬化的存在与 DM 无关。在这项具有超过 20 年随访的基于人群的队列研究中,HBV 感染对 DM 的发展没有影响。