铑催化的具有四膦配体的苯乙烯高区域选择性氢氨甲基化反应。

Rhodium-catalyzed highly regioselective hydroaminomethylation of styrenes with tetraphosphorus ligands.

机构信息

College of Science, Northwest A&F University , Yangling, Shaanxi 712100, P. R. China, and, Department of Chemistry and Chemical Biology, Rutgers, the State University of New Jersey , Piscataway, New Jersey 08854, United States.

出版信息

Org Lett. 2013 Jun 21;15(12):3078-81. doi: 10.1021/ol4012635. Epub 2013 Jun 3.

DOI:10.1021/ol4012635

PMID:23730853

Abstract

The highly linear-selective hydroaminomethylation of styrenes is very challenging. Herein, an efficient, highly chemoselective, and linear-selective hydroaminomethylation (l/b up to >99:1) of styrenes using Rh(nbd)2SbF6 with a pyrrole-based 3,3',5,5'-substituted tetraphosphorus ligand is documented. This is in sharp contrast to other available processes leading to branched amines and provides a novel atom economic approach to 3-arylpropylamines.

摘要

高线性选择性的苯乙烯氢氨甲基化反应极具挑战性。在此，我们使用基于吡咯的 3,3',5,5'-取代四磷配体的 Rh(nbd)2SbF6 高效、高化学选择性和高线性选择性地实现了苯乙烯的氢氨甲基化（l/b 高达>99:1）。这与其他导致支链胺的现有方法形成鲜明对比，为 3-芳基丙胺提供了一种新颖的原子经济性方法。