Kruse W, Weber E
Krankenhaus Bethanien, Heidelberg, FRG.
Eur J Clin Pharmacol. 1990;38(6):561-5. doi: 10.1007/BF00278582.
The utility of a new microprocessor-based method for continuous monitoring of compliance in taking solid medicaments has been evaluated. Medication intake in 31 ambulant patients was assessed in a prospective observational study under the conditions of routine practice. The patients (aged 14-87 y, mean 50 y) were receiving long-term drug treatment for various chronic diseases. There was marked interindividual and intraindividual variation in compliance with different drugs. Deviations from the prescribed dosage regimens were caused by omission of doses (22.7% of prescribed doses) and intake of extra doses (5.6% of prescribed doses). Continuous monitoring revealed that in 19% of the monitoring period no medication was taken, in 13% there was partial intake, and in 8% extra doses were taken. Patient-initiated drug holidays occurred in 50% of patients. They were responsible for 76% of the medication-free time. It is concluded, that continuous compliance monitoring is practicable in ambulatory patients. It provides information about the dynamics of drug intake behaviour that cannot be obtained from medical histories or from clinical or laboratory examination. The information could be used effectively in individual patient care and in clinical drug trials.
一种基于微处理器的新型连续监测固体药物服用依从性方法的实用性已得到评估。在常规实践条件下，通过一项前瞻性观察研究对31名门诊患者的药物摄入情况进行了评估。这些患者（年龄在14 - 87岁之间，平均50岁）因各种慢性疾病接受长期药物治疗。不同药物的依从性存在明显的个体间和个体内差异。与规定剂量方案的偏差是由漏服剂量（占规定剂量的22.7%）和多服剂量（占规定剂量的5.6%）引起的。连续监测显示，在19%的监测期内未服药，13%有部分服药情况，8%有多服剂量的情况。50%的患者出现了自行停药期。它们占无药时间的76%。得出的结论是，连续依从性监测在门诊患者中是可行的。它提供了有关药物摄入行为动态的信息，这些信息无法从病史或临床及实验室检查中获得。这些信息可有效地用于个体患者护理和临床药物试验。
