免疫功能正常的复发性单纯疱疹病毒性角膜炎患者的阿昔洛韦耐药性角膜单纯疱疹病毒 1 分离株的表型和基因型特征。
Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis.
机构信息
UPMC Univ Paris 06, ER1 DETIV, F-75013 Paris, France.
出版信息
J Clin Virol. 2013 Sep;58(1):321-4. doi: 10.1016/j.jcv.2013.05.001. Epub 2013 May 31.
PMID:23731845
Abstract
Herpes simplex virus type 1 (HSV-1) is a leading cause of corneal blindness. Acyclovir (ACV) constitutes the standard treatment of HSV infections including herpetic keratitis (HK). HSV resistance to ACV is mainly described in immunocompromised patients. We describe two cases of ACV-resistant corneal HSV-1 in immunocompetent individuals with recurrent HK.
摘要
单纯疱疹病毒 1 型（HSV-1）是导致角膜盲的主要原因。阿昔洛韦（ACV）是治疗包括单纯疱疹性角膜炎（HK）在内的 HSV 感染的标准药物。ACV 耐药性主要见于免疫功能低下的患者。我们描述了两例免疫功能正常的复发性 HK 患者出现 ACV 耐药性角膜 HSV-1 的病例。
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