免疫功能正常患者的阿昔洛韦耐药性水痘带状疱疹病毒角膜炎。
Acyclovir-resistant varicella-zoster virus keratitis in an immunocompetent patient.
机构信息
Ophthalmology Department, Charles Nicolle University Hospital, Rouen, France.
出版信息
J Clin Virol. 2013 Sep;58(1):318-20. doi: 10.1016/j.jcv.2013.04.024. Epub 2013 Jun 4.
PMID:23756055
Abstract
Varicella-zoster virus (VZV) resistance to acyclovir (ACV) has only been reported in rare cases of immunocompromised patients. We report the first case of an immunocompetent patient with ACV-resistant VZV keratitis associated with a nucleotide deletion in the VZV thymidine kinase gene, leading to production of a truncated protein.
摘要
水痘带状疱疹病毒（VZV）对阿昔洛韦（ACV）的耐药性仅在少数免疫功能低下的患者中报告过。我们报告了首例免疫功能正常的患者出现 ACV 耐药性 VZV 角膜炎，与 VZV 胸苷激酶基因中的核苷酸缺失有关，导致产生截短蛋白。
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