Zhang Jie, Liu Huan, Wei Bin
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
J Zhejiang Univ Sci B. 2017;18(4):277-288. doi: 10.1631/jzus.B1600460.
Herpes simplex virus type 1 (HSV-1), a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of T cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine candidates for HSV-1.
单纯疱疹病毒1型（HSV-1）是α疱疹病毒家族的嗜神经成员，是最普遍且成功的人类病原体之一。HSV-1可在生命的各个阶段引发严重疾病，包括新生儿致命性播散性疾病、唇疱疹、眼部疾病以及成人致命性脑炎。HSV-1感染可触发快速免疫反应，而对HSV-1感染的有效抑制和清除依赖于宿主的固有免疫反应和适应性免疫反应。HSV-1采用多种策略来限制宿主的固有免疫反应，以促进其在宿主细胞中的感染。宿主的适应性免疫在抑制HSV-1感染中起重要作用。T细胞的激活和调节是适应性免疫的重要方面。它们在宿主介导的免疫中起关键作用，对于清除HSV-1很重要。在本综述中，我们研究了HSV-1感染期间T细胞免疫反应的相关发现，这些发现为设计新型HSV-1候选疫苗带来了希望。
