Gabelt B T, Kaufman P L
Department of Ophthalmology, University of Wisconsin Medical School, Madison 53792.
Exp Eye Res. 1990 Jul;51(1):87-91. doi: 10.1016/0014-4835(90)90174-s.
Cynomolgus monkeys were treated topically in one eye with 2 micrograms of prostaglandin F2 alpha -l-isopropylester (PGF2 alpha-IE) twice daily. On day 4, 3 hr after the seventh dose, intraocular pressure (IOP) was 8.1 +/- 0.7 mmHg lower in the treated than in the control eyes. On day 5, after the ninth PGF2 alpha dose, gross facility was measured in both eyes by determining the rate of fluid flow from an external reservoir into the eye at two different IOP levels. Simultaneously, trabecular facility was measured by determining the rate of accumulation of intracamerally infused radioiodinated albumin in the general circulation. Gross facility was 40-60% higher in PGF2 alpha treated than in control eyes, but there was no difference in trabecular facility. The increase in gross facility sometimes reported following PGF2 alpha probably represents increased pseudofacility or uveoscleral facility, rather than true facility of outflow through the trabecular meshwork and Schlemm's canal.
将食蟹猴的一只眼睛每天局部用2微克前列腺素F2α -l-异丙酯（PGF2α-IE）治疗两次。在第4天，第七次给药后3小时，治疗眼的眼内压（IOP）比对照眼低8.1±0.7 mmHg。在第5天，第九次给予PGF2α后，通过在两个不同的IOP水平下测定从外部储液器流入眼内的液体流速来测量两只眼睛的总流出易度。同时，通过测定房室内注入的放射性碘化白蛋白在体循环中的积累速率来测量小梁流出易度。PGF2α治疗组的总流出易度比对照组高40 - 60%，但小梁流出易度没有差异。PGF2α治疗后有时报道的总流出易度增加可能代表假性流出易度或葡萄膜巩膜流出易度增加，而不是通过小梁网和施莱姆管的真正流出易度增加。
