Division of Infectious Disease, Department of Internal Medicine, Emory University School of Medicine, Atlanta, GA 30308, USA.
Obstet Gynecol Clin North Am. 2013 Jun;40(2):339-57. doi: 10.1016/j.ogc.2013.02.005. Epub 2013 May 10.
Human papillomavirus (HPV) is a sexually transmitted virus that is associated with increased risk of anogenital cancers in immunosuppressed hosts. The behavior of HPV infection is controlled by the systemic immune system response as well as the local tissue immune system to the HPV virus. Individuals with a depressed immune system, either by viral infection (such as human immunodeficiency virus) or by chronic immunosuppressive agents (such as transplant recipients or patients with autoimmune disease) are at an increased risk of HPV-associated malignancies. This article addresses the data and limitations in developing evidence-driven guidelines for cervical cancer screening in immunocompromised women.
人乳头瘤病毒（HPV）是一种性传播病毒，与免疫抑制宿主的肛门生殖器癌症风险增加有关。HPV 感染的行为受全身免疫系统反应以及局部组织免疫系统对 HPV 病毒的控制。由于病毒感染（如人类免疫缺陷病毒）或慢性免疫抑制剂（如移植受者或自身免疫性疾病患者）而免疫系统受到抑制的个体，HPV 相关恶性肿瘤的风险增加。本文针对制定针对免疫功能低下女性宫颈癌筛查的循证指南的数据和局限性进行了探讨。
