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炎症性肠病患者女性健康问题的最新进展

Updates on Women's Health Issues in Patients with Inflammatory Bowel Disease.

作者信息

Bonthala Nirupama, Kane Sunanda

机构信息

Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA, USA.

Department of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN, 55905, USA.

出版信息

Curr Treat Options Gastroenterol. 2018 Mar;16(1):86-100. doi: 10.1007/s11938-018-0172-4.

Abstract

PURPOSE OF REVIEW

Inflammatory bowel disease affects approximately 800,000 women in the USA with the peak incidence between ages 15 to 40. Thus for many females, IBD can impact nearly every stage of their life from menarche to pregnancy, menopause, and beyond. This paper will review the most recent updates on the topics of sexual health, cervical cancer screening, menstruation, fertility, contraception, and menopause.

RECENT FINDINGS

Menarche can be delayed in females especially those who are underweight, malnourished, or with active inflammatory bowel disease. Cyclical GI symptoms during a menstrual cycle are very common in women with IBD and should not be confused with flares. Overall fertility is similar to the general population unless females with IBD have had significant abdominal surgery but reassuringly this infertility appears to be restored with the use of in vitro fertilization. Discussion regarding family planning is imperative in women with IBD with a strong recommendation to consider long-acting highly effective contraceptives such as intrauterine devices or implants. Cervical cancer screening should be tailored in women on immunosuppressive medications and all women under 26 years of age should be advised to receive the human papilloma virus vaccination. As gastroenterologists will have longitudinal relationships with their female IBD patients, they must be knowledgeable about sex-specific issues during each stage of life from puberty to after menopause to optimize their patient's care.

摘要

综述目的

在美国,炎症性肠病影响着约80万名女性,发病高峰年龄在15至40岁之间。因此,对于许多女性来说,炎症性肠病几乎会影响她们从初潮到怀孕、绝经及之后的每一个生活阶段。本文将综述性健康、宫颈癌筛查、月经、生育、避孕和绝经等主题的最新进展。

最新发现

初潮在女性中可能会延迟,尤其是那些体重过轻、营养不良或患有活动性炎症性肠病的女性。月经周期中的周期性胃肠道症状在炎症性肠病女性中非常常见,不应与病情发作相混淆。总体生育率与普通人群相似,除非患有炎症性肠病的女性接受过重大腹部手术,但令人欣慰的是,这种不孕症似乎可以通过体外受精得以恢复。对于炎症性肠病女性,计划生育的讨论至关重要,强烈建议考虑使用长效高效避孕药具,如宫内节育器或植入物。宫颈癌筛查应针对服用免疫抑制药物的女性进行调整,所有26岁以下的女性都应被建议接种人乳头瘤病毒疫苗。由于胃肠病学家与女性炎症性肠病患者会有长期的关系,他们必须了解从青春期到绝经后生活各阶段的性别特异性问题,以优化对患者的护理。

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