Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
EuroIntervention. 2013 May;9 Suppl R:R105-9. doi: 10.4244/EIJV9SRA18.
Sleep apnoea occurs in 5% to 10% of the general population. Obstructive sleep apnoea (OSA) is the most common disease associated with resistant hypertension. In a paper published by Pedrosa et al, OSA - defined as an apnoea-hypopnoea index (AHI) >15 events/hour measured in polysomnography -was diagnosed in 64% of patients with resistant hypertension. OSA is also considered as an independent risk factor for cardiovascular events: ischaemic heart disease, heart failure, stroke and death. Several mechanisms, including oxidative stress, inflammation and endothelial dysfunction may be responsible for the association between OSA and cardiovascular disease. Continuous positive airway pressure (CPAP) is a treatment of choice to reverse severe OSA and its consequences.
睡眠呼吸暂停在普通人群中的发生率为 5%至 10%。阻塞性睡眠呼吸暂停（OSA）是与难治性高血压相关的最常见疾病。在 Pedrosa 等人发表的一篇论文中，OSA 被定义为多导睡眠图测量的每小时呼吸暂停-低通气指数（AHI）>15 次，在难治性高血压患者中，64%的患者被诊断为 OSA。OSA 也被认为是心血管事件的独立危险因素：缺血性心脏病、心力衰竭、中风和死亡。一些机制，包括氧化应激、炎症和内皮功能障碍，可能是 OSA 与心血管疾病之间关联的原因。持续气道正压通气（CPAP）是逆转严重 OSA 及其后果的首选治疗方法。
