University Heart Center, University Hospital Zurich, Zurich, Switzerland.
EuroIntervention. 2013 May;9 Suppl R:R155-60. doi: 10.4244/EIJV9SRA26.
Despite lifestyle modification and pharmacological approaches, the rates of control of blood pressure are still not optimal. Experimental and clinical studies suggest that renal denervation therapy is an effective and safe treatment for patients with therapy-resistant hypertension leading to a reduction in blood pressure and in systemic and renal sympathetic nervous activation, which plays an important role in the development, progression and prognosis of arterial hypertension. Moreover, besides blood pressure reduction, renal denervation improves glucose metabolism, left ventricular hypertrophy and diastolic function in patients with resistant hypertension. Actually, many small clinical studies suggest that renal denervation may also be useful in diseases other than hypertension such as metabolic syndrome, sleep-related breathing disorders, chronic kidney disease and renal failure, chronic heart failure and polycystic ovary syndrome.
尽管进行了生活方式的改变和药物治疗，但血压控制率仍然不理想。实验和临床研究表明，肾去神经治疗对于治疗抵抗性高血压患者是一种有效且安全的治疗方法，可降低血压和全身及肾脏交感神经激活，这在动脉高血压的发生、进展和预后中起着重要作用。此外，除了降低血压外，肾去神经还可改善抵抗性高血压患者的葡萄糖代谢、左心室肥厚和舒张功能。实际上，许多小型临床研究表明，肾去神经治疗在高血压以外的疾病中也可能有用，如代谢综合征、睡眠相关呼吸障碍、慢性肾脏病和肾衰竭、慢性心力衰竭和多囊卵巢综合征。
