Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Level 11, Building 75, Missenden Road, Camperdown, NSW 2050, Australia.
Respir Physiol Neurobiol. 2013 Aug 15;188(2):165-71. doi: 10.1016/j.resp.2013.05.031. Epub 2013 May 31.
This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide P CO2, pH and bicarbonate (HCO3(-)) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42-46°C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann-Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG-ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for P Co2: mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) -2.7-3.6 mmHg (± 6.6%); pH: MD -0.008 (-0.1%), LOA -0.023-0.008 (± 0.2%); and HCO3(-): MD -0.3 mmol L(-1) (-1.0%), LOA -1.8-1.2 mmol L(-1) (± 5.3%). AVBG provides valid measures of [Formula: see text] , pH, and HCO3(-) in OHS.
这项前瞻性研究调查了动脉化静脉血气（AVBG）在估计肥胖低通气综合征（OHS）患者动脉二氧化碳 P CO2、pH 和碳酸氢盐（HCO3(-)）方面的有效性。在 42-46°C 加热皮肤后，从上肢静脉获得 AVBG。同时采集动脉血气（ABG）和 AVBG 样本，并使用 Bland-Altman 分析进行比较。使用独立 t 检验或 Mann-Whitney U 检验评估组间差异。分析了 42 对可行的配对样本，包括 15 名 OHS 参与者的 27 对配对样本和 16 名对照者的 15 对配对样本。AVBG-ABG 一致性在组间、手部背侧、前臂和肘前 AVBG 采样部位之间没有差异，并且对于 P Co2 是临床可接受的：平均差值（MD）为 0.4 mmHg（0.9%），一致性界限（LOA）为-2.7-3.6 mmHg（±6.6%）；pH：MD-0.008（-0.1%），LOA-0.023-0.008（±0.2%）；HCO3(-)：MD-0.3 mmol L(-1)（-1.0%），LOA-1.8-1.2 mmol L(-1)（±5.3%）。AVBG 可提供 OHS 中[Formula: see text]、pH 和 HCO3(-) 的有效测量值。
