动脉化静脉血 PCO2、pH 值和碳酸氢盐在肥胖低通气综合征中的有效性。

Validity of arterialised-venous P CO2, pH and bicarbonate in obesity hypoventilation syndrome.

机构信息

Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Level 11, Building 75, Missenden Road, Camperdown, NSW 2050, Australia.

出版信息

Respir Physiol Neurobiol. 2013 Aug 15;188(2):165-71. doi: 10.1016/j.resp.2013.05.031. Epub 2013 May 31.

DOI:10.1016/j.resp.2013.05.031

PMID:23732508

Abstract

This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide P CO2, pH and bicarbonate (HCO3(-)) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42-46°C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann-Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG-ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for P Co2: mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) -2.7-3.6 mmHg (± 6.6%); pH: MD -0.008 (-0.1%), LOA -0.023-0.008 (± 0.2%); and HCO3(-): MD -0.3 mmol L(-1) (-1.0%), LOA -1.8-1.2 mmol L(-1) (± 5.3%). AVBG provides valid measures of [Formula: see text] , pH, and HCO3(-) in OHS.

摘要

这项前瞻性研究调查了动脉化静脉血气（AVBG）在估计肥胖低通气综合征（OHS）患者动脉二氧化碳 P CO2、pH 和碳酸氢盐（HCO3(-)）方面的有效性。在 42-46°C 加热皮肤后，从上肢静脉获得 AVBG。同时采集动脉血气（ABG）和 AVBG 样本，并使用 Bland-Altman 分析进行比较。使用独立 t 检验或 Mann-Whitney U 检验评估组间差异。分析了 42 对可行的配对样本，包括 15 名 OHS 参与者的 27 对配对样本和 16 名对照者的 15 对配对样本。AVBG-ABG 一致性在组间、手部背侧、前臂和肘前 AVBG 采样部位之间没有差异，并且对于 P Co2 是临床可接受的：平均差值（MD）为 0.4 mmHg（0.9%），一致性界限（LOA）为-2.7-3.6 mmHg（±6.6%）；pH：MD-0.008（-0.1%），LOA-0.023-0.008（±0.2%）；HCO3(-)：MD-0.3 mmol L(-1)（-1.0%），LOA-1.8-1.2 mmol L(-1)（±5.3%）。AVBG 可提供 OHS 中[Formula: see text]、pH 和 HCO3(-) 的有效测量值。