大鼠巨结肠

Megacolon in rats.

作者信息

Oliveira J S, Llorach-Velludo M A, Sales-Neto V N

机构信息

Department of Pathology, Faculty of Medicine, Ribeirão Preto (SP), Brazil.

出版信息

Digestion. 1990;45(3):166-71. doi: 10.1159/000200239.

DOI:10.1159/000200239

PMID:2373271

Abstract

Four months of sigmoid colon intrinsic denervation of young male Wistar rats resulted in typical megacolon. Average 46.0% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in a 480-nm extension of the treated segment. Increased thickness of the megacolon wall was due to muscle hypertrophy (+117.4%) and mucosal hyperplasia (+53.9%) as shown by morphometry. The potential usefulness of this experimental model is emphasized.

摘要

对年轻雄性Wistar大鼠的乙状结肠进行四个月的内在去神经支配导致了典型的巨结肠。通过在浆膜上涂抹苯扎氯铵（0.2% v/v），获得了平均46.0%的奥尔巴赫神经丛去神经支配。通过对处理段480纳米延伸段中的神经节细胞计数来评估去神经支配情况。形态计量学显示，巨结肠壁厚度增加是由于肌肉肥大（+117.4%）和黏膜增生（+53.9%）。强调了该实验模型的潜在用途。