Garcia S B, Pinto L Z, Zucoloto S, Oliveira J S
Department of Morphology, Faculty of Medicine of Ribeirão Preto, SP, Brazil.
Res Exp Med (Berl). 1995;195(4):249-53. doi: 10.1007/BF02576795.
Typical megaileum occurred in young male Wistar rats three months after ileum myenteric plexus denervation. An average of 58.4% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in an 8 nm ring-shaped histological sectfrom the midportion of the treated segment. A morphometric study showed that the increased thickness of the megaileum wall was due to muscle hypertrophy and mucosal hyperplasia. The potential usefulness of this model of megaileum is emphasized.
