基于干细胞的疗法预防骨折延迟愈合：一项随机前瞻性初步研究。
Stem cell-based therapy for prevention of delayed fracture union: a randomized and prospective preliminary study.
机构信息
Department of Orthopedic Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
出版信息
Mol Ther. 2013 Aug;21(8):1631-8. doi: 10.1038/mt.2013.109. Epub 2013 Jun 4.
Abstract
Distal tibial fractures tend towards delayed- or nonunion. The purpose of this study was to evaluate the safety and efficacy of early minimally invasive intervention (MII) in the treatment of these fractures. A total 24 consecutive patients who underwent operative treatment for distal tibial fractures were randomized into a control and an intervention group. MII entailed aspirating iliac crest bone marrow and peripheral blood, yielding mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) respectively, that were mixed with demineralized bone matrix (DBM) and injected under fluoroscopic control into the fracture site. No complications occurred in either group. The median time to union was 1.5 months in the MII group and 3 months in the control group. MII was found to be a safe and efficient procedure.
摘要
胫骨远端骨折容易出现延迟愈合或不愈合。本研究旨在评估早期微创干预（MII）治疗这些骨折的安全性和疗效。共 24 例接受手术治疗的胫骨远端骨折患者随机分为对照组和干预组。MII 包括抽吸髂嵴骨髓和外周血，分别获得间充质干细胞（MSCs）和富含血小板的血浆（PRP），将其与脱钙骨基质（DBM）混合，并在透视控制下注入骨折部位。两组均未发生并发症。干预组的愈合时间中位数为 1.5 个月，对照组为 3 个月。MII 被发现是一种安全有效的方法。
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