Department of Neurology, Comparative Effectiveness, Cost and Outcomes Research Center, University of Washington, Seattle, WA 359455, USA.
J Clin Neurophysiol. 2013 Jun;30(3):280-6. doi: 10.1097/WNP.0b013e3182933d8f.
To construct a cost-benefit model for intraoperative neurophysiological monitoring (IOM) in spinal surgeries.
Decision model was based on sensitivity, specificity, IOM cost, prevention rate given an IOM alert, and spinal procedure neurologic complication rates in pooled estimates from the published literature with outcome of lifetime costs after neuromonitored versus unmonitored spinal surgeries. Lifetime cost of neurologic injury was the sum of direct health care costs and lost wages and benefits. Results from Monte Carlo simulation with 10,000 replications were analyzed for cost outcomes and relationship of input variables to outcomes.
IOM saved $23,189 (P < 0.001) for the reference case of 50-year-olds with neurologic complication rate of 5%, 2009 Medicare reimbursement of IOM at $1,535 per operation, 52.4% prevention rate given an IOM alert at 94.3% sensitivity and 95.6% specificity, assuming incomplete (nonplegic) motor injury. The baseline risk of surgery, lifetime costs after neurologic deficit, and ability to prevent neurologic deficits after an IOM alert were most correlated with cost outcomes. In linear prediction models, IOM remained cost-saving when neurologic complication rate from surgery exceeded 0.3% (P < 0.001) and prevention rate after IOM alert was greater than 14.2%(P = 0.02).
Intraoperative monitoring is cost-saving for spinal surgeries in a theoretical model based on the current published literature.
构建脊柱手术中术中神经生理监测(IOM)的成本效益模型。
决策模型基于灵敏度、特异性、IOM 成本、IOM 警报的预防率以及从已发表文献中汇总的脊柱手术神经并发症发生率,以及神经监测与未监测脊柱手术后的终生成本结果。神经损伤的终生成本是直接医疗费用和工资及福利损失的总和。使用蒙特卡罗模拟进行了 10,000 次复制,分析了成本结果以及输入变量与结果的关系。
在参考情况下,即 50 岁患者的神经并发症率为 5%、2009 年 Medicare 对 IOM 的报销为每次手术 1535 美元、IOM 警报的预防率为 52.4%(灵敏度为 94.3%,特异性为 95.6%),假设不完全(非截瘫)运动损伤,IOM 节省了 23,189 美元(P < 0.001)。基线手术风险、神经功能缺损后的终生成本以及在 IOM 警报后预防神经功能缺损的能力与成本结果最相关。在线性预测模型中,当手术神经并发症率超过 0.3%(P < 0.001)和 IOM 警报后的预防率大于 14.2%(P = 0.02)时,IOM 仍然具有成本效益。
基于当前已发表文献,在理论模型中,IOM 对脊柱手术具有成本效益。