The Stowers Institute for Medical Research, Kansas City, MO, USA.
J Glaucoma. 2013 Jun-Jul;22 Suppl 5:S42-5. doi: 10.1097/IJG.0b013e3182934b45.
Retinal neuronal death causes a severe and irreversible loss of visual function in the patients of retinitis pigmentosa, age-related macular degeneration and glaucoma, but these degenerative diseases currently still lack effective medical treatments. The restorative properties of stem cells hold the promise in the treatment of these retinal degenerative diseases. The exciting progress has been made on stem cell research in the last decade. Many different stem cell types have been explored for their potential in treating the retinal degenerative diseases, including embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells and retinal stem cells. This review will summarize the recent progress in this exciting area.
视网膜神经元死亡导致色素性视网膜炎、年龄相关性黄斑变性和青光眼患者的严重且不可逆转的视觉功能丧失，但这些退行性疾病目前仍然缺乏有效的治疗方法。干细胞的修复特性为治疗这些视网膜退行性疾病带来了希望。在过去的十年中，干细胞研究取得了令人兴奋的进展。许多不同类型的干细胞因其在治疗视网膜退行性疾病方面的潜力而被探索，包括胚胎干细胞、诱导多能干细胞、间充质干细胞和视网膜干细胞。本综述将总结这一令人兴奋领域的最新进展。
