Ramsden Conor M, Powner Michael B, Carr Amanda-Jayne F, Smart Matthew J K, da Cruz Lyndon, Coffey Peter J
The London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London, London, UK.
Dev Ophthalmol. 2014;53:97-110. doi: 10.1159/000357363. Epub 2014 Apr 10.
Retinal degeneration represents a huge burden of blinding disease, and currently there are no effective treatments that reverse the most common causes of neural retinal degeneration. Stem cell biology has the potential to significantly ease this burden, not only through the development of disease models of retinal degeneration but also in the manufacture of a replacement for the neural retinal tissue. This review summarizes the major advancements in the last decade in the field of neural retinal regeneration with an emphasis on the differentiation of embryonic and induced pluripotent stem cells into cells with retinal and specifically photoreceptor characteristics.
视网膜变性是致盲疾病的一个巨大负担，目前尚无有效的治疗方法来逆转神经视网膜变性的最常见病因。干细胞生物学不仅有潜力通过开发视网膜变性疾病模型，还能通过制造神经视网膜组织替代品来显著减轻这一负担。本文综述了过去十年神经视网膜再生领域的主要进展，重点阐述了胚胎干细胞和诱导多能干细胞向具有视网膜特别是光感受器特性的细胞分化的情况。
