University of Basel, Head of Neuro-ophthalmology, Kantonsspital Aarau, Aarau, Switzerland.
J Glaucoma. 2013 Jun-Jul;22 Suppl 5:S8-10. doi: 10.1097/IJG.0b013e318293498b.
The function of cerebrospinal fluid (CSF) is to protect the brain and optic nerve from mechanical damage, provide nutrition for axons/neurons, and remove of toxic metabilites. CSF is produced mainly by the choroid plexus epithelium and ependymal cells of the ventricles and flows into interconnecting chambers; namely, the cisterns and the subarachnoid spaces. Based on studies of CSF circulation and direction of flow using radioisotopes and other tracers injected into the CSF, it is thought that there is a bulk circulation of fluid from the sites of production in the third, fourth, and lateral ventricles to the arachnoid villi and probably to the lymphatic capillaries in the cranial dura mater. The mechanism by which CSF is propelled is incompletely understood, but probably is influenced by the release of newly produced CSF, ventricular pulsations, and the pulse pressure of the vascular choroid plexus. This mechanism would account for the steady CSF pressure. In addition to the steady CSF pressure, overlapping pressure spikes occur during trunk inclination, coughing and other valsalva.
脑脊液（CSF）的功能是保护大脑和视神经免受机械损伤，为轴突/神经元提供营养，并清除有毒代谢物。CSF 主要由脉络丛上皮和脑室的室管膜细胞产生，并流入相互连接的腔室，即脑池和蛛网膜下腔。基于放射性同位素和其他示踪剂注入 CSF 后 CSF 循环和流动方向的研究，人们认为存在一种从第三、第四和侧脑室的产生部位到蛛网膜绒毛并可能到颅骨硬脑膜中的淋巴毛细血管的大量液体循环。CSF 被推动的机制尚不完全清楚，但可能受新产生的 CSF 的释放、脑室搏动和脉管脉络丛的脉搏压力的影响。这种机制可以解释稳定的 CSF 压力。除了稳定的 CSF 压力外，在躯干倾斜、咳嗽和其他valsalva 期间还会出现重叠的压力尖峰。
