Department of Hematology, The Second Hospital, Hebei Medical University, Shijiazhuang, Hebei 050000, PR China.
Oncol Rep. 2013 Aug;30(2):1007-13. doi: 10.3892/or.2013.2518. Epub 2013 Jun 4.
Chronic myelogenous leukemia (CML) has a typical progressive course with transition from a chronic phase to a terminal blast crisis phase. However, the mechanisms that lead to disease progression remain unclear. Bone marrow mesenchymal stem cells (BMMSCs) play important roles in maintaining the bone marrow microenvironment. In the present study, the biological characteristics of BMMSCs were determined including proliferation, apoptosis and secretion of cytokines during blastic phase CML (CML-Bp). The effect of BMMSCs in CML-Bp on K562 human CML cells and the CML-Bp original generation leukemia cells were also explored. Our results showed that CML-Bp BMMSCs protect tumor cells and increase their anti-apoptotic ability through regulating the expression of apoptosis-related proteins and activating the Wnt pathway.
慢性髓细胞白血病（CML）具有典型的进行性病程，从慢性期过渡到终末期急变期。然而，导致疾病进展的机制仍不清楚。骨髓间充质干细胞（BMMSCs）在维持骨髓微环境中发挥重要作用。在本研究中，我们确定了 CML 急变期（CML-Bp）BMMSCs 的生物学特性，包括增殖、凋亡和细胞因子分泌。还探讨了 CML-Bp BMMSCs 对 K562 人 CML 细胞和 CML-Bp 原始生成白血病细胞的影响。我们的结果表明，CML-Bp BMMSCs 通过调节凋亡相关蛋白的表达和激活 Wnt 通路，保护肿瘤细胞并增加其抗凋亡能力。
