TiO2 纳米颗粒对斑马鱼（Danio rerio）的光毒性取决于生命阶段。
Phototoxicity of TiO2 nanoparticles to zebrafish (Danio rerio) is dependent on life stage.
机构信息
Mid-Continent Ecology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Duluth, Minnesota, USA.
出版信息
Environ Toxicol Chem. 2013 Sep;32(9):2139-43. doi: 10.1002/etc.2298. Epub 2013 Jul 19.
Zebrafish embryos have been used increasingly to evaluate nanomaterial toxicity. The present study compared phototoxicity of TiO2 nanoparticles with zebrafish at 4 life stages (embryos, yolk-sac larvae, free-swimming larvae, and juvenile) under simulated sunlight using the 96-h standard toxicity assay. Yolk-sac larvae were found to be the most sensitive to TiO2 phototoxicity, suggesting that the widely used zebrafish embryo test may not fully or accurately predict hazard and risk of these nanoparticles to small fish.
斑马鱼胚胎已被越来越多地用于评估纳米材料的毒性。本研究使用 96 小时标准毒性测定法，在模拟太阳光下比较了 TiO2 纳米颗粒在斑马鱼的 4 个生命阶段（胚胎、卵黄囊幼虫、自由游动幼虫和幼鱼）中的光毒性。结果发现，卵黄囊幼虫对 TiO2 光毒性最为敏感，这表明广泛使用的斑马鱼胚胎试验可能无法充分或准确地预测这些纳米颗粒对小鱼的危害和风险。
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