Schmidt Morgen C, Andersen A M N, Due P, Neelon S B, Gamborg M, Sørensen T I A
Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Pediatr Obes. 2014 Aug;9(4):239-48. doi: 10.1111/j.2047-6310.2013.00177.x. Epub 2013 Jun 4.
Overweight may hinder achievement of gross motor milestones and delayed achievement of milestones may increase the risk of later overweight for reasons involving physical activity and the building of lean body mass.
To investigate whether increased birth weight and body mass index (BMI) at 5 months is associated with the achievement of the ability to sit up and walk and whether delayed achievement of these milestones is associated with overweight at age 7 years.
We used data from the Danish National Birth Cohort on 25,148 children born between 1998 and 2003. Follow-up took place from 2003 to 2010. Mean age at follow-up was 7.04 years. We used logistic and linear regression analyses.
Birth weight and BMI at 5 months were marginally associated with earlier achievement of the ability to sit up and walk (regression coefficients between -0.027 months; [CI -0.042; -0.013] and -0.092 months [CI -0.118; -0.066]). Age in months of sitting and walking were not associated with overweight at age 7 years (ORs between 0.97 [CI 0.95-1.00] and 1.00 [CI 0.96-1.04]). Later achievement of sitting and walking predicted lower BMI at age 7 years (ln-BMI -z-scores between -0.023 [CI -0.029; -0.017] and -0.005 [CI -0.015; 0.005)).
All observed associations were of negligible magnitude and we conclude that birth weight or BMI at age 5 months and motor milestones appear largely independent of each other and that timing of achievement of motor milestones seems not to be associated with later overweight or increased BMI.
超重可能会阻碍大运动发育里程碑的达成，而发育里程碑的延迟达成可能会因身体活动和瘦体重的增长等因素增加日后超重的风险。
调查出生体重增加及5个月时的体重指数（BMI）是否与坐立和行走能力的达成有关，以及这些发育里程碑的延迟达成是否与7岁时的超重有关。
我们使用了丹麦国家出生队列中1998年至2003年间出生的25148名儿童的数据。随访时间为2003年至2010年。随访时的平均年龄为7.04岁。我们采用了逻辑回归和线性回归分析。
出生体重和5个月时的BMI与较早达成坐立和行走能力存在微弱关联（回归系数在-0.027个月；[可信区间-0.042；-0.013]和-0.092个月[可信区间-0.118；-0.066]之间）。坐立和行走的月龄与7岁时的超重无关（比值比在0.97[可信区间0.95-1.00]和1.00[可信区间0.96-1.04]之间）。坐立和行走较晚达成预示着7岁时BMI较低（自然对数BMI z分数在-0.023[可信区间-0.029；-0.017]和-0.005[可信区间-0.015；0.005]之间）。
所有观察到的关联程度都可忽略不计，我们得出结论，5个月时的出生体重或BMI与运动发育里程碑在很大程度上相互独立，运动发育里程碑的达成时间似乎与日后的超重或BMI增加无关。
