串联钌-亚烷基催化交叉复分解/氢化：亲脂性氨基酸的合成。
Tandem Ru-alkylidene-catalysed cross metathesis/hydrogenation: synthesis of lipophilic amino acids.
机构信息
School of Chemistry, Monash University, Wellington Road, Melbourne, 3800, Victoria, Australia.
出版信息
J Pept Sci. 2013 Aug;19(8):470-6. doi: 10.1002/psc.2522. Epub 2013 Jun 3.
DOI:10.1002/psc.2522
PMID:23733491
Abstract
Highly efficient synthesis of lipidic amino acids can be achieved via Ru-alkylidene-catalysed cross metathesis of long chain alkenes with commercially available allylglycine. The resultant unsaturated analogues can be then optionally hydrogenated under mild reaction conditions by using the spent metathesis catalyst.
摘要
通过 Ru-亚烷基催化的长链烯烃与商业可得的烯丙基甘氨酸的交叉复分解反应，可以高效合成脂族氨基酸。所得的不饱和类似物可以在温和的反应条件下使用用过的复分解催化剂进行加氢。
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