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Novel deprotection method of Fmoc group under neutral hydrogenation conditions.

作者信息

Maegawa Tomohiro, Fujiwara Yuta, Ikawa Takashi, Hisashi Hideo, Monguchi Yasunari, Sajiki Hironao

机构信息

Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.

出版信息

Amino Acids. 2009 Mar;36(3):493-9. doi: 10.1007/s00726-008-0109-7. Epub 2008 May 27.

DOI:10.1007/s00726-008-0109-7
PMID:18504523
Abstract

Novel deprotection method of the Fmoc (9-flurorenylmethoxycarbonyl) protective group under Pd/C-catalyzed hydrogenation conditions at room temperature was developed. The addition of CH(3)CN accelerated the deprotection of the Fmoc group, and also the application of H(2) pressure (3 atm) shows notable rate enhancement.

摘要

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