Department of Physiology Development and Neuroscience, University of Cambridge Cambridge, UK.
Front Neurosci. 2013 May 23;7:81. doi: 10.3389/fnins.2013.00081. eCollection 2013.
RNA localization and regulation play an important role in the developing and adult nervous system. In navigating axons, extrinsic cues can elicit rapid local protein synthesis that mediates directional or morphological responses. The mRNA repertoire in axons is large and dynamically changing, yet studies suggest that only a subset of these mRNAs are translated after cue stimulation, suggesting the need for a high level of translational regulation. Here, we review the role of RNA-binding proteins (RBPs) as local regulators of translation in developing axons. We focus on their role in growth, guidance, and synapse formation, and discuss the mechanisms by which they regulate translation in axons.
RNA 定位和调控在发育和成年神经系统中起着重要作用。在引导轴突的过程中，外在线索可以引发快速的局部蛋白质合成，从而介导定向或形态响应。轴突中的 mRNA 种类繁多且不断变化，但研究表明，只有一小部分 mRNA 在受到线索刺激后被翻译，这表明需要高水平的翻译调控。在这里，我们回顾了 RNA 结合蛋白 (RBPs) 在发育中的轴突中作为翻译的局部调节剂的作用。我们重点讨论它们在生长、导向和突触形成中的作用，并讨论它们在轴突中调节翻译的机制。
