Noubom Michel, Kenfack Bruno, Donfack Jean Hubert, Nembot Fabrice Djouma, Sando Zacharie
Department of Biomedical Sciences, University of Dschang, Cameroon.
Pan Afr Med J. 2013 Apr 4;14:131. doi: 10.11604/pamj.2013.14.131.2387. Print 2013.
Botryomycome also called pyogenic granuloma, is an inflammatory tumor of the skin and mucous membranes often caused by superinfection of minor traumatism. Its uniqueness lies in its granulomatous organization in which each granulation contains bacteria and the predominance of many newly formed blood vessels, with the lights on variables ratings and a turgid endothelium responsible for the ulcero-hemorragic appearance. This delicate condition poses a real problem of treatment which included: an appropriate antibiotherapy, surgical removal or electrocoagulation which, until today is more difficult in countries with limited income. An octogenarian came to our hospital with a large mass on the left foot. This mass had the appearance of a malignant tumor. However, the anatomopathologic diagnosis showed that it was a pyogenic granuloma. The importance of the mass, its location on the sole of the foot, imposed the functional impairment of this member. Electrocoagulation is not available in our hospital and the surgical excision proposed was refused by the patient. The patient was treated with the antibiotics Ceftriaxone and Gentalline at indicated doses for 15 days. After the failure of that antibiotherapy treatment, as a last resort, the patient was treated for a month with another combination of antibiotics (free of cost) made of dapsone and rifampicin. This new combination gave very good results. This example shows dapsone and rifampicin can be use as a new weapon for the management of pyogenic granuloma in countries with limited incomes.
葡萄状菌病也称为脓性肉芽肿，是一种皮肤和黏膜的炎性肿瘤，常由轻微创伤后的继发感染引起。其独特之处在于其肉芽肿组织，其中每个肉芽都含有细菌，且有许多新形成的血管占优势，其透明度有不同等级，肿胀的内皮导致溃疡出血外观。这种棘手的病症带来了一个实际的治疗问题，包括：适当的抗生素治疗、手术切除或电凝术，而在收入有限的国家，直到今天，这些治疗都更加困难。一位八旬老人来到我们医院，左脚有一个大肿块。这个肿块看起来像恶性肿瘤。然而，解剖病理学诊断显示它是脓性肉芽肿。肿块的大小及其在脚底的位置导致该肢体功能受损。我们医院没有电凝设备，建议的手术切除被患者拒绝。患者接受了头孢曲松和庆大霉素的指定剂量治疗，为期15天。在那次抗生素治疗失败后，作为最后手段，患者用由氨苯砜和利福平组成的另一种抗生素组合（免费）治疗了一个月。这种新组合取得了很好的效果。这个例子表明，在收入有限的国家，氨苯砜和利福平可作为治疗脓性肉芽肿的新武器。
