携带白细胞介素-15的高密度脂蛋白
High-density lipoproteins delivering interleukin-15.
作者信息
Ochoa Maria C, Melero Ignacio, Berraondo Pedro
机构信息
Division of Hepatology and Gene Therapy; Center for Applied Medical Research, and University Clinic; University of Navarra, Pamplona; Navarra, Spain.
出版信息
Oncoimmunology. 2013 Apr 1;2(4):e23410. doi: 10.4161/onci.23410.
Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved in IL-15 trans-presentation.
就稳定性和生物分布而言，循环脂蛋白作为细胞因子和激素的治疗载体可能具有有趣的特性。载脂蛋白A-I与白细胞介素-15（IL-15）融合可将后者靶向高密度脂蛋白（HDL）。通过与参与IL-15反式呈递的IL-15受体α结构域形成三联体融合，这种嵌合体的生物活性可进一步增强。
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