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树突状细胞在抗肿瘤免疫调节中的作用。

Role of dendritic cells in the regulation of antitumor immunity.

作者信息

Wathelet Nathalie, Moser Muriel

机构信息

Laboratory of Immunobiology; Department of Molecular Biology; Université Libre de Bruxelles (ULB); Gosselies, Belgium.

出版信息

Oncoimmunology. 2013 Apr 1;2(4):e23973. doi: 10.4161/onci.23973.

DOI:10.4161/onci.23973
PMID:23734333
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3654603/
Abstract

The majority of rodent and human tumors express antigens that can be recognized by T lymphocytes and are infiltrated by immune cells. Although tumor infiltration by T lymphocytes has been associated with a favorable prognosis, the role of dendritic cells (DCs), which may present tumor-associated antigens in an immunogenic or tolerogenic context, remains elusive. Here, we discuss recent observations suggesting that the function of DCs in the tumor microenvironment may impact the spontaneous resistance of neoplasms to chemotherapy as well as treatment outcome.

摘要

大多数啮齿动物和人类肿瘤表达的抗原可被T淋巴细胞识别，并且有免疫细胞浸润。虽然T淋巴细胞的肿瘤浸润与良好的预后相关，但树突状细胞（DC）在免疫原性或耐受性环境中呈递肿瘤相关抗原的作用仍不清楚。在此，我们讨论最近的观察结果，提示肿瘤微环境中DC的功能可能影响肿瘤对化疗的自发抗性以及治疗结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/253c/3654603/609d0647d81a/onci-2-e23973-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/253c/3654603/10c3fa7498f6/onci-2-e23973-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/253c/3654603/609d0647d81a/onci-2-e23973-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/253c/3654603/10c3fa7498f6/onci-2-e23973-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/253c/3654603/609d0647d81a/onci-2-e23973-g2.jpg

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本文引用的文献

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