胃肿瘤的内镜显微镜检查与靶向成像
Endomicroscopy and targeted imaging of gastric neoplasia.
作者信息
Goetz Martin
机构信息
Deptartment of Medicine I, University of Tübingen, Otfried-Müller-Str. 10, 72076 Tübingen, Germany.
出版信息
Gastrointest Endosc Clin N Am. 2013 Jul;23(3):597-606. doi: 10.1016/j.giec.2013.03.004. Epub 2013 May 10.
Confocal laser endomicroscopy (CLE) allows microscopic imaging of the gastric mucosa in real time during endoscopy. Gastroenterologists are able to evaluate gastric pathologies in real time, which is used to target fewer biopsies to regions of interest by providing multiple "optical" biopsies, and guide endoscopic interventions. CLE provides a powerful tool for translational studies to unravel the pathophysiology of diseases in vivo virtually free of artifacts. Molecular imaging may help to detect suspicious lesions and to predict response to targeted therapy. This review provides an overview of current applications of endomicroscopy of the stomach in clinical and translational science.
共聚焦激光内镜检查（CLE）可在内镜检查过程中对胃黏膜进行实时显微成像。胃肠病学家能够实时评估胃部病变，通过提供多次“光学”活检，将较少的活检目标定位到感兴趣的区域，并指导内镜干预。CLE为转化研究提供了一个强大的工具，以在体内揭示疾病的病理生理学，几乎没有伪像。分子成像可能有助于检测可疑病变并预测靶向治疗的反应。本文综述了胃内显微内镜在临床和转化科学中的当前应用概况。
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