Neumann Helmut, Kiesslich Ralf
Interdisciplinary Endoscopy, Department of Medicine I, University of Erlangen-Nuremberg, Ulmenweg 18, Erlangen 91054, Germany.
Gastrointest Endosc Clin N Am. 2013 Jul;23(3):695-705. doi: 10.1016/j.giec.2013.03.006. Epub 2013 May 8.
Two types of endomicroscopy systems exist. One is integrated into a standard, high-resolution endoscope and one is probe-based, capable of passage through the working channel of a standard endoscope. Endocytoscopy allows visualization of the superficial mucosal layer. Endoscope-integrated and probe-based devices allow magnification of the mucosa up to 1400-fold. Endomicroscopy can differentiate histologic changes of Crohn disease and ulcerative colitis in vivo in real time. Endocytoscopy can discriminate mucosal inflammatory cells, allowing determination of histopathologic activity of ulcerative colitis. Molecular imaging with fluorescence-labeled probes against disease-specific receptors will enable individualized management of inflammatory bowel diseases.
存在两种类型的内镜显微镜系统。一种集成到标准的高分辨率内窥镜中，另一种是基于探头的，能够通过标准内窥镜的工作通道。内镜细胞成像术可实现对浅表粘膜层的可视化。内镜集成式和基于探头的设备可将粘膜放大至1400倍。内镜显微镜可在体内实时鉴别克罗恩病和溃疡性结肠炎的组织学变化。内镜细胞成像术能够区分粘膜炎症细胞，从而确定溃疡性结肠炎的组织病理学活性。使用针对疾病特异性受体的荧光标记探针进行分子成像将实现炎症性肠病的个体化管理。
