Regnier Shane M, Sargis Robert M
Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, IL, USA.
Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, IL, USA; Kovler Diabetes Center, University of Chicago, Chicago, IL, USA; Section of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago, IL, USA.
Biochim Biophys Acta. 2014 Mar;1842(3):520-33. doi: 10.1016/j.bbadis.2013.05.028. Epub 2013 Jun 2.
The burgeoning obesity epidemic has placed enormous strains on individual and societal health mandating a careful search for pathogenic factors, including the contributions made by endocrine disrupting chemicals (EDCs). In addition to evidence that some exogenous chemicals have the capacity to modulate classical hormonal signaling axes, there is mounting evidence that several EDCs can also disrupt metabolic pathways and alter energy homeostasis. Adipose tissue appears to be a particularly important target of these metabolic disruptions. A diverse array of compounds has been shown to alter adipocyte differentiation, and several EDCs have been shown to modulate adipocyte physiology, including adipocytic insulin action and adipokine secretion. This rapidly emerging evidence demonstrating that environmental contaminants alter adipocyte function emphasizes the potential role that disruption of adipose physiology by EDCs may play in the global epidemic of metabolic disease. Further work is required to better characterize the molecular targets responsible for mediating the effects of EDCs on adipose tissue. Improved understanding of the precise signaling pathways altered by exposure to environmental contaminants will enhance our understanding of which chemicals pose a threat to metabolic health and how those compounds synergize with lifestyle factors to promote obesity and its associated complications. This knowledge may also improve our capacity to predict which synthetic compounds may alter energy homeostasis before they are released into the environment while also providing critical evidentiary support for efforts to restrict the production and use of chemicals that pose the greatest threat to human metabolic health. This article is part of a Special Issue entitled: Modulation of Adipose Tissue in Health and Disease.
迅速蔓延的肥胖症流行给个人和社会健康带来了巨大压力，这就需要我们仔细寻找致病因素，包括内分泌干扰化学物质（EDC）的影响。除了有证据表明一些外源性化学物质能够调节经典的激素信号轴外，越来越多的证据表明，几种EDC还会扰乱代谢途径并改变能量平衡。脂肪组织似乎是这些代谢紊乱的一个特别重要的靶点。已显示多种化合物可改变脂肪细胞分化，并且几种EDC已被证明可调节脂肪细胞生理功能，包括脂肪细胞的胰岛素作用和脂肪因子分泌。这一迅速出现的证据表明环境污染物会改变脂肪细胞功能，强调了EDC对脂肪生理的干扰可能在全球代谢疾病流行中所起的潜在作用。需要进一步开展工作，以更好地确定介导EDC对脂肪组织影响的分子靶点。更好地了解暴露于环境污染物后改变的精确信号通路，将增进我们对哪些化学物质对代谢健康构成威胁以及这些化合物如何与生活方式因素协同作用以促进肥胖及其相关并发症的理解。这些知识还可能提高我们在合成化合物释放到环境之前预测哪些化合物可能改变能量平衡的能力，同时也为限制生产和使用对人类代谢健康构成最大威胁的化学物质的努力提供关键的证据支持。本文是名为：健康与疾病中脂肪组织的调节的特刊的一部分。
