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骨密度测量结果前后初级保健中骨质疏松症的管理:实际治疗与指南推荐治疗。CANAL研究。

Management of osteoporosis in primary care before and after the result of densitometry: treatments in real practice versus the recommended by guidelines. CANAL study.

作者信息

Naranjo Antonio, Rosas José, Ojeda Soledad, Salas Esteban

机构信息

Servicio de Reumatología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.

出版信息

Reumatol Clin. 2013 Sep-Oct;9(5):269-73. doi: 10.1016/j.reuma.2013.01.011. Epub 2013 Jun 2.

DOI:10.1016/j.reuma.2013.01.011
PMID:23735224
Abstract

OBJECTIVES

To analyze the requirements for osteoporosis (OP) treatment of primary care physicians (PCP), before and after knowing the result of a bone densitometry (DXA).

MATERIAL AND METHODS

We studied 50 years older women from two Spanish health areas (Canary Islands and Alicante). The FRAX risk factors were collected and we reviewed the requirements for OP treatment before DXA and in the subsequent months (bisphosphonates, strontium, raloxifene/bazedoxifene, estrogens, parathyroid hormone). To evaluate the appropriateness of treatment we used published guidelines. A high risk for hip fracture was considered if FRAX ≥ 3% or the patient had a history of fragility fracture

RESULTS

We included 339 women (mean age: 63 years). Before DXA, 14% of Canarias and 58% of Alicante were receiving treatment. Thirty seven percent of treated patients and 26% of the untreated patients had a high fracture risk before DXA. The average FRAX for a high risk of fracture and hip fracture was 5.6% and 2%, respectively. After DXA, the percentage of treated patients rose from 35 to 39%: increasing from 14 to 28% in the Canary Islands and decreasing from 58 to 51% in Alicante. Overall, treatment was received by 64% of patients with OP, 38% of patients with osteopenia and 15% of those with normal DXA. When the OP treatment guidelines were applied, we found that 7% needed treatment according to the most restrictive guidelines and 43% according to the most flexible guidelines.

CONCLUSIONS

There is great variability in treatment for OP prescribed before after DXA between GP. A broad consensus guideline between different specialties is required to optimize clinical practice.

摘要

目的

分析基层医疗医生(PCP)在知晓骨密度测定(DXA)结果前后对骨质疏松症(OP)治疗的需求。

材料与方法

我们研究了来自西班牙两个卫生区域(加那利群岛和阿利坎特)的50岁以上女性。收集了FRAX风险因素,并回顾了DXA之前及随后几个月(双膦酸盐、锶、雷洛昔芬/巴多昔芬、雌激素、甲状旁腺激素)对OP治疗的需求。为评估治疗的适当性,我们采用了已发表的指南。如果FRAX≥3%或患者有脆性骨折病史,则认为存在髋部骨折高风险。

结果

我们纳入了339名女性(平均年龄:63岁)。在DXA之前,加那利群岛14%的患者和阿利坎特58%的患者正在接受治疗。在DXA之前,37%的接受治疗患者和26%的未治疗患者有高骨折风险。骨折和髋部骨折高风险的平均FRAX分别为5.6%和2%。DXA之后,接受治疗患者的百分比从35%升至39%:在加那利群岛从14%增至28%,在阿利坎特从58%降至51%。总体而言,64%的OP患者、38%的骨量减少患者和15%的DXA正常患者接受了治疗。当应用OP治疗指南时,我们发现根据最严格的指南7%的患者需要治疗,根据最宽松的指南43%的患者需要治疗。

结论

全科医生在DXA前后开出的OP治疗方案存在很大差异。需要不同专科之间达成广泛的共识指南以优化临床实践。

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