Institute for Neuroimmunology and Clinical MS Research (INiMS), Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf, Falkenried 94, 20251 Hamburg, Germany.
J Neuroimmunol. 2013 Aug 15;261(1-2):108-19. doi: 10.1016/j.jneuroim.2013.05.004. Epub 2013 Jun 2.
Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.
中性粒细胞胞外陷阱（NETs）能够非常有效地捕获和杀死病原体，但也会激活树突状细胞并使 T 细胞致敏。此前，我们证明在复发缓解型多发性硬化症（RRMS）中，中性粒细胞被致敏且循环 NETs 水平升高，RRMS 是一种 T 细胞介导的自身免疫性疾病。在此，我们在 RRMS 患者中证明了循环 NETs 存在性别特异性差异，但中性粒细胞的致敏作用则没有性别差异。尽管我们对这些患者进行了系统而深入的特征分析，结果并不支持循环 NETs 在该疾病中起主要作用，但这提示 NETs 可能是 MS 发病机制中性别特异性差异的基础。
